Polymorphism and peripheral levels of apolipoprotein(a) in
polygenic hypercholesterolemia and combined hyperlipidemia
Garry X. Shen
David Mymin
Thomas Dembinski
Andrew Krahn
Aubie Angel
Departments of Internal Medicine and Clinical
Chemistry, University of Manitoba, Winnipeg,
Manitoba
(Original manuscript submitted 6/1/94; received in revised form
8/6/94; accepted 15/8/94)
Abstract
This study demonstrates that peripheral apolipoprotein(a) [apo(a)]
levels are higher in patients with polygenic hypercholesterolemia
(PH) and combined hyperlipidemia (CH) than in controls. Levels of
apo(a) inversely correlate with apo(a) isoform sizes. For a given
apo(a) isoform, apo(a) levels are higher in PH and CH patients.
Higher frequencies of smaller apo(a) isoforms were found in PH and
CH patients than in controls, and in patients with coronary artery
disease (CAD) or a family history of premature cardiovascular
diseases than in patients without CAD or family history.
Clin Invest Med 1995; 18 (1): 33-41
Table of contents: CIM vol. 18, no. 1
Copyright 1996 Canadian Medical Association