Diagnosis and management of acromegaly

Table 1: Pathologic conditions associated with growth-hormone hypersecretion

Primary pituitary disorders

Primary pituitary adenoma

  • Densely granulated growth-hormone cell adenoma
  • Sparsely granulated growth-hormone cell adenoma
  • Mixed somatotrophic–lactotrophic adenoma
  • Mammosomatotrophic adenoma
  • Acidophilic stem-cell adenoma
  • Plurihormonal adenoma
    Somatotrophic carcinoma
    Lymphocytic hypophysitis

    Secondary pituitary disorders

    Somatotrophic hyperplasia secondary to

  • Eutopic growth-hormone-releasing hormone (GHRH) hypersecretion (hamartoma)
  • Ectopic GHRH hypersecretion (carcinoid)
  • McCune–Albright syndrome