Renal natriuretic effects of atrial natriuretic peptide in dogs with alloxan-induced acute pulmonary edema

Table 2: Effects of atrial natriuretic peptide (ANF) administration during alloxan-induced pulmonary edema in six dogs
 Mean (and standard error of the mean)
Result Before alloxan administration After alloxan administration After administration
of ANF
During recovery
Urinary flow, mL/min 0.29  (0.02) 1.27*  (0.13) 3.45*  (0.32) 1.90*  (0.27)
Urinary sodium excretion, µmol/min 93  (16) 212*  (13) 376*  (44) 120*  (21)
Glomerular filtration rate, mL/min 55  (3.7) 41*  (4.1) 40  (3.9) 39  (4)
Para-amino hippurate clearance, mL/min 178  (12) 164  (14) 123*  (16) 120  (9.9)
Plasma protein concentration, g/L 49  (0.9) 48  (0.8) 44*  (0.7) 45  (1.1)
Hematocrit 0.375  (0.012) 0.395*  (0.017) 0.358*  (0.019) 0.373*  (0.017)
Central venous pressure, cm H20 5.3  (0.9) 5.3  (0.8) 4.5*  (0.8) 4.5  (0.9)
Arterial blood pressure, mm Hg 100  (10) 90*  (11) 90  (9) 105*  (10.5)
*p < 0.05 compared to the previous experimental phase.

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