Table 3: Results of alloxan administration during renal arterial clamping in five dogs | |||||
Mean (and standard error of the mean) | |||||
Result | Before ANF or alloxan administration | After first administration of ANF | During recovery | After administration of alloxan | After second administration of ANF |
Urinary flow, mL/min | 0.75 (0.11) | 2.67* (0.5) | 1.68* (0.28) | 0.81* (0.17) | 1.78* (0.36) |
Urinary sodium excretion, µmol/min | 108 (9) | 355* (14) | 75* (8) | 58* (9) | 132* (10) |
Glomerular filtration rate, mL/min | 33 (1.2) | 33 (1.3) | 31 (2.6) | 24* (3.0) | 26 (3.4) |
Para-amino hippurate clearance, mL/min | 95 (11) | 93 (13) | 96 (14) | 80* (8.8) | 88 (11) |
Plasma protein concentration, g/L | 46 (0.8) | 49* (0.9) | 47* (0.9) | 43* (1.0) | 43 (1.3) |
Hematocrit | 0.38 (0.010) | 0.41* (0.013) | 0.41 (0.012) | 0.44* (0.012) | 0.44 (0.014) |
Central venous pressure, cm H20 | 7.0 (0.8) | 7.0 (0.8) | 6.5* (0.9) | 6.5 (0.9) | 7.0* (1.0) |
Arterial blood pressure, mm Hg | 110 (11) | 90* (12) | 100* (10) | 100 (9.5) | 90* (8.8) |
*p < 0.05 compared with the previous experimental phase. |