Renal natriuretic effects of atrial natriuretic peptide in dogs with alloxan-induced acute pulmonary edema

Table 3: Results of alloxan administration during renal arterial clamping in five dogs
 Mean (and standard error of the mean)
Result Before ANF or alloxan administration After first administration of ANF During recovery After administration of alloxan After second administration of ANF
Urinary flow, mL/min 0.75  (0.11) 2.67*  (0.5) 1.68*  (0.28) 0.81*  (0.17) 1.78*  (0.36)
Urinary sodium excretion, µmol/min 108  (9) 355*  (14) 75*  (8) 58*  (9) 132*  (10)
Glomerular filtration rate, mL/min 33  (1.2) 33  (1.3) 31  (2.6) 24*  (3.0) 26  (3.4)
Para-amino hippurate clearance, mL/min 95  (11) 93  (13) 96  (14) 80*  (8.8) 88  (11)
Plasma protein concentration, g/L 46  (0.8) 49*  (0.9) 47*  (0.9) 43*  (1.0) 43  (1.3)
Hematocrit 0.38  (0.010) 0.41*  (0.013) 0.41  (0.012) 0.44*  (0.012) 0.44  (0.014)
Central venous pressure, cm H20 7.0  (0.8) 7.0  (0.8) 6.5*  (0.9) 6.5  (0.9) 7.0*  (1.0)
Arterial blood pressure, mm Hg 110  (11) 90*  (12) 100*  (10) 100  (9.5) 90*  (8.8)
*p < 0.05 compared with the previous experimental phase.

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