Renal natriuretic effects of atrial natriuretic peptide in dogs with alloxan-induced acute pulmonary edema

Table 4: Results of ANF administration after isoncotic dextran solution infusion in four dogs
 Mean (and standard error of the mean)
Result Before ANF or alloxan administration After administration of alloxan and dextran After administration of ANF During recovery
Urinary flow, mL/min 0.29  (0.03) 1.77*  (0.16) 3.75*  (0.44) 2.9*  (0.28)
Urinary sodium excretion, µmol/min 62  (12) 245*  (19) 462*  (23) 179*  (16)
Glomerular filtration rate, mL/min 38  (3) 22*  (3.4) 23  (3.3) 19  (2.7)
Para-amino hippurate clearance, mL/min 135  (14) 148  (12) 119*  (11) 95*  (9.3)
Plasma protein concentration, g/L 48  (0.8) 42*  (0.7) 43  (0.9) 43  (0.9)
Hematocrit 0.42  (0.017) 0.36*  (0.014) 0.37  (0.014) 0.425*  (0.013)
Central venous pressure, cm H20 7  (0.08) 7  (0.7) 7  (0.7) 6*  (0.9)
Arterial blood pressure, mm Hg 100  (8.6) 100  (9.3) 80*  (7.0) 100*  (12.0)
*p < 0.05 compared with the previous experimental phase.

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