Thyroid xenografts from patients with Graves' disease in severe combined immunodeficient mice and NIH-beige-nude-xid mice

Table 1: Immunologic characteristics of thyroid tissue donors and NIH-beige-nude xid (NIH-3) and severe combined immunodeficient (SCID) mice that received xenografts with human thyroid tissue
			No. of mice with a detectable level of antibodies, out of total no. of mice with xenografts from donor				Maximum antibody titre,* U/mL, or IgG level, mg/L in mice
	Antibody titres in donors*		NIH-3		SCID		NIH-3			SCID
Donor	TPO­Ab†	Tg­Ab††	TPO­Ab	Tg­Ab	TPO­Ab	Tg­Ab	TPO­Ab	Tg­Ab	IgG	TPO­Ab	Tg­Ab	IgG
1	4.6	-	1/3	0/3	0/2	0/2	1.3	-	105	-	-		176
2	-	-	0/2	0/2	1/2	0/2	-	-	864	2.5	-		1513
3	729.0	4.2	1/1	1/1	1/1	1/1	279.0	62.0	968	205.0	44.0		396
4	1133.0	3.7	3/3	3/3	3/3	3/3	82.0	6.5	1076	154.0	18.5		1513
5	418.0	-	3/3	0/3	3/3	0/3	292.0	-	612	126.3	-		216
6	207.0	48.0	2/2	0/2	2/2	1/2	1.1	-	104	62.0	2.5		612
* TPO­Ab and Tg­Ab levels of more than 1.0 U/mL are considered positive. † TPO-Ab = thyroperoxidase antibody. †† Tg-Ab = thyroglobulin.

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