Thyroid xenografts from patients with Graves' disease in severe combined immunodeficient mice and NIH-beige-nude-xid mice

Table 2: Immunologic characteristics of donors of peripheral blood mononuclear cells (PBMC) and of NIH-3 and SCID mice that received xenografts with human PBMC

No. of mice with a detectable level of antibodies, out of total no. of mice with xenografts from donor

Maximum antibody titre,*
U/mL, or IgG level, mg/L in mice

Antibody titres in donors*
NIH-3
SCID
NIH-3
SCID
Donor
TPO­Ab
Tg­Ab
TPO­Ab
Tg­Ab
TPO­Ab
Tg­Ab
TPO­Ab
Tg­Ab
IgG
TPO­Ab
Tg­Ab
IgG
1
42.9
29.4
0/1
0/1
0/1
0/1
-
-
-
-
0
0
2
-
-
0/1
0/1
0/1
0/1
-
-
2246
-
-
0
3
4.6
-
0/1
0/1
0/1
0/1
-
-
0
-
-
0
4
124.7
94.4
0/1
0/1
0/1
0/1
-
-
0
-
-
0
5
-
-
0/1
0/1
0/1
0/1
-
-
556
-
-
28
6
-
-
0/1
0/1
0/1
0/1
-
-
0
-
-
0
7
-
-
0/1
0/1
0/1
0/1
-
-
1029
-
-
2246
8
4.3
-
0/1
0/1
0/1
0/1
-
-
1029†
-
-
0
9
231.0
3.8
1/1
0/1
1/1
0/1
5.9
0.8
1112†
8.2
-
2924
10
1133.0
3.7
0/1
0/1
1/1
1/1
-
-
44†
10.2
1.0
3600
11
85.6
5.1
0/1
0/1
0/1
0/1
-
-
0
-
-
0
12
418.0
-
0/1
0/1
1/1
0/1
0.7
-
1350
1.8
-
1480
*TPO­Ab and Tg­Ab levels of more than 1.0 U/mL are considered positive.
† The mouse had died.

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