| Table 1: Scores for severity and frequency of cerebral lesions in various groups of SHRSP (scoring system explained in Methods) | ||||
| Group; mean score (and standard error of the mean [SEM]) | ||||
| Type of brain lesion | Control n = 6 |
8-week treatment/ withdrawal n = 6 |
12-week treatment/withdrawal n = 5 |
24-week treatment/ withdrawal n = 7* |
| Infarction | ||||
| Severity | 16(6) | 40(10) | 16†(8) | 4†(2) |
| Frequency | 2(1) | 4(1) | 2(1) | 1†(1) |
| Thrombosis | ||||
| Severity | 17(6) | 33(11) | 12(4) | 4†(4) |
| Frequency | 2(1) | 3(1) | 1(1) | 1†(1) |
| Fibrinoid necrosis of vessel wall | ||||
| Severity | 18(5) | 33(11) | 12(4) | 4†(4) |
| Frequency | 2(1) | 3(1) | 1 | 1†(1) |
| Microvascular proliferation | ||||
| Severity | 26(6) | 49(11) | 24(10) | 7‡(4) |
| Frequency | 3 | 5(1) | 3(1) | 1 |
| Fibrinous exudate or edema | ||||
| Severity | 18(6) | 33(11) | 13(6) | 4†(4) |
| Frequency | 2(1) | 3(1) | 2(1) | 1(1) |
| Hemorrhage | ||||
| Severity | 22(7) | 35(7) | 13†(6) | 2‡(1) |
| Frequency | 3(1) | 5(1) | 2(1) | 1‡(1) |
| Malacia | ||||
| Severity | 19(5) | 47(10) | 20†(9) | 6‡(5) |
| Frequency | 2(1) | 5(1) | 2(1) | 1†(1) |
| Rarefaction | ||||
| Severity | 19†(4) | 52(12) | 25†(11) | 0‡ |
| Frequency | 3(1) | 5(1) | 3†(1) | 0‡ |
| Cystic structure in neuropil | ||||
| Severity | 6†(2) | 31(7) | 13†(8) | 1‡(1) |
| Frequency | 1† | 4(1) | 2†(1) | 0‡ |
| Gliosis | ||||
| Severity | 26(6) | 55(11) | 27†(11) | 10‡(6) |
| Frequency | 4(1) | 5(1) | 3(1) | 1†(1) |
| Leukocytic infiltration | ||||
| Severity | 15(5) | 30(8) | 15(7) | 2†(1) |
| Frequency | 2(1) | 4(1) | 2(2) | 0 |
| Total | ||||
| Severity | 201†(52) | 438(101) | 190(80) | 43‡(30) |
| Frequency | 25(5) | 46(10) | 22(9) | 8†(5) |
|
*Treatment groups receiving 1 and 4 mg/kg per day were combined.
†p < 0.05 compared with 8-week treatment/withdrawal group. ‡p < 0.01 compared with 8-week treatment/withdrawal group. |
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