Prevention of stroke with perindopril treatment in stroke-prone spontaneously hypertensive rats

Table 1: Scores for severity and frequency of cerebral lesions in various groups of SHRSP (scoring system explained in Methods)
  Group; mean score (and standard error of the mean [SEM])
Type of brain lesion Control
n = 6
8-week
treatment/ withdrawal
n = 6
12-week
treatment/withdrawal
n = 5
24-week
treatment/ withdrawal
n = 7*
Infarction
Severity 16(6) 40(10) 16†(8) 4†(2)
Frequency 2(1) 4(1) 2(1) 1†(1)
Thrombosis
Severity 17(6) 33(11) 12(4) 4†(4)
Frequency 2(1) 3(1) 1(1) 1†(1)
Fibrinoid necrosis of vessel wall
Severity 18(5) 33(11) 12(4) 4†(4)
Frequency 2(1) 3(1) 1 1†(1)
Microvascular proliferation
Severity 26(6) 49(11) 24(10) 7‡(4)
Frequency 3 5(1) 3(1) 1
Fibrinous exudate or edema
Severity 18(6) 33(11) 13(6) 4†(4)
Frequency 2(1) 3(1) 2(1) 1(1)
Hemorrhage
Severity 22(7) 35(7) 13†(6) 2‡(1)
Frequency 3(1) 5(1) 2(1) 1‡(1)
Malacia
Severity 19(5) 47(10) 20†(9) 6‡(5)
Frequency 2(1) 5(1) 2(1) 1†(1)
Rarefaction
Severity 19†(4) 52(12) 25†(11) 0‡
Frequency 3(1) 5(1) 3†(1) 0‡
Cystic structure in neuropil
Severity 6†(2) 31(7) 13†(8) 1‡(1)
Frequency 1† 4(1) 2†(1) 0‡
Gliosis
Severity 26(6) 55(11) 27†(11) 10‡(6)
Frequency 4(1) 5(1) 3(1) 1†(1)
Leukocytic infiltration
Severity 15(5) 30(8) 15(7) 2†(1)
Frequency 2(1) 4(1) 2(2) 0
Total
Severity 201†(52) 438(101) 190(80) 43‡(30)
Frequency 25(5) 46(10) 22(9) 8†(5)
*Treatment groups receiving 1 and 4 mg/kg per day were combined.
p < 0.05 compared with 8-week treatment/withdrawal group.
p < 0.01 compared with 8-week treatment/withdrawal group.

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| CIM: October 1997 (vol 20, no 5) / MCE : octobre 1997 (vol 20, no 5) |

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