| Table 2: Severity of lesions and arteriolar thickening in the kidneys of SHRSP from various groups | |||||||
| Group; % of kidney affected, except where noted | |||||||
| Type of lesions | Control n = 5 |
8-week treatment n = 6 |
8-week treatment/ withdrawal n = 5 |
12-week treatment n = 6 |
12-week treatment/withdrawal n = 5 |
24-week treatment/ withdrawal n = 5 |
|
| Fibrinoid necrosis | 40(7) | 0*†(0) | 87*(8) | 0*†(0) | 72‡(13) | 67‡(11) | |
| Glomerular lesions | 13(8) | 11†(7) | 80§(8) | 13† (8) | 67§ (9) | 67§ (0) | |
| Tubulointerstitial lesions | 40(7) | 0†§(0) | 100§(0) | 7†§(7) | 94§ (6) | 87§ (8) | |
| Arteriolar thickening, mm (and SEM) | 27(3) | 21||(3) | 38 (4) | 28 (3) | 45‡ (4) | 44‡ (6) | |
|
*p < 0.01 compared with control group.
‡p < 0.05 compared with control group. †p < 0.001 compared with treatment/withdrawal groups. §p < 0.001 compared with control group. ||p < 0.05 compared with treatment/withdrawal groups. | |||||||