Periodic health examination, 1995 update: 1. Screening for human papillomavirus infection in asymptomatic women

Table 1: Reported prevalence of human papillomavirus (HPV) infection*

Study Type of Study Screening Tests Patient Population Results

Syrjanen et al, Finland, 1990[22] Population-based survey Papanicolaou smear 63 115 women aged 20 to 65 yr HPV rate 0.8% overall; 6.1% among those 20 to 29 yr and 2.2% among those 30 to 39 yr

De Villiers et al, Germany, 1987[24] Survey Papanicolaou smear, filter insitu DNA hybridization 9 295 women seen at outpatient gynecology clinics HPV rate 10% to 13% among those 15 to 50 yr and 2% to 5% among those over 55 yr

Collins et al, Hong Kong, 1990[25] Survey Papanicolaou smear, insitu DNA hybridization 215 pregnant women HPV rate 1.5% through Papanicolaou testing and 5% through DNA hybridization

Rohan et al, Canada, 1991[26] Survey PCR 105 women from a student health clinic HPV rate 18.1% overall, 2.9% for HPV-6 and -11, and 10.5% for HPV-16 and -18

Fisher et al, United States 1991[27] Survey Southern blot technique 107 female adolescents at a suburban adolescent health service HPV rate 32% overall

McKinnon et al, Australia, 1991[28] Survey Papanicolaou smear, cervicography 245 women aged 16 to 53 yr at an STD clinic HPV rate 41% overall (18% through Papanicolaou testing); 20.4% among those with CIN (8.2% through Papanicolaou testing)

Van den Brule et al, the Netherlands, 1991[29] Survey Papanicolaou smear, PCR 1 346 asymptomatic women, 593 gynecology outpatients HPV rates for those with normal smears were 3.5% among asymptomatic women and 14% among outpatients; HPV rates for those with abnormal smears were 70% among women with mild dysplasia, 84% among those with severe dysplasia and 100% among those with CIN

Horn et al, United States, 1991[30] Survey Papanicolaou smear, Southern blot technique 116 women at an STD clinic 17% had visible warts, 41% had an abnormal Papanicolaou smear, and 12% had a positive Southern blot result

Mandal et al, Britain, 1991[31] Survey Cytologic examination, DNA hybridization 105 asymptomatic men at an STD clinic HPV rate 40% overall, 27% by cytologic examination and 20% by DNA hybridization

Chow et al, Singapore, 1991[32] Case series Coloscopy 25 male partners of women with genital HPV infection or CIN Subclinical HPV infection in 88%

*PCR = polymerase chain reaction, STD = sexually transmitted disease, CIN = cervical intraepithelial neoplasia.

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Table 1: Reported prevalence of human papillomavirus (HPV) infection*
Study	Type of Study	Screening Tests	Patient Population	Results
Syrjanen et al, Finland, 1990[22]	Population-based survey	Papanicolaou smear	63 115 women aged 20 to 65 yr	HPV rate 0.8% overall; 6.1% among those 20 to 29 yr and 2.2% among those 30 to 39 yr
De Villiers et al, Germany, 1987[24]	Survey	Papanicolaou smear, filter insitu DNA hybridization	9 295 women seen at outpatient gynecology clinics	HPV rate 10% to 13% among those 15 to 50 yr and 2% to 5% among those over 55 yr
Collins et al, Hong Kong, 1990[25]	Survey	Papanicolaou smear, insitu DNA hybridization	215 pregnant women	HPV rate 1.5% through Papanicolaou testing and 5% through DNA hybridization
Rohan et al, Canada, 1991[26]	Survey	PCR	105 women from a student health clinic	HPV rate 18.1% overall, 2.9% for HPV-6 and -11, and 10.5% for HPV-16 and -18
Fisher et al, United States 1991[27]	Survey	Southern blot technique	107 female adolescents at a suburban adolescent health service	HPV rate 32% overall
McKinnon et al, Australia, 1991[28]	Survey	Papanicolaou smear, cervicography	245 women aged 16 to 53 yr at an STD clinic	HPV rate 41% overall (18% through Papanicolaou testing); 20.4% among those with CIN (8.2% through Papanicolaou testing)
Van den Brule et al, the Netherlands, 1991[29]	Survey	Papanicolaou smear, PCR	1 346 asymptomatic women, 593 gynecology outpatients	HPV rates for those with normal smears were 3.5% among asymptomatic women and 14% among outpatients; HPV rates for those with abnormal smears were 70% among women with mild dysplasia, 84% among those with severe dysplasia and 100% among those with CIN
Horn et al, United States, 1991[30]	Survey	Papanicolaou smear, Southern blot technique	116 women at an STD clinic	17% had visible warts, 41% had an abnormal Papanicolaou smear, and 12% had a positive Southern blot result
Mandal et al, Britain, 1991[31]	Survey	Cytologic examination, DNA hybridization	105 asymptomatic men at an STD clinic	HPV rate 40% overall, 27% by cytologic examination and 20% by DNA hybridization
Chow et al, Singapore, 1991[32]	Case series	Coloscopy	25 male partners of women with genital HPV infection or CIN	Subclinical HPV infection in 88%