Guidelines for red blood cell and plasma transfusion for adults and children

 

Table 2: Advantages and disadvantages of autologous blood transfusion
AdvantagesDisadvantages
Reduces exposure to allogeneic blood

Reduces risk of transmissible viral infections

  • alloimmune hemolysis
  • allergic reactions
  • immunization to foreign antigens
  • graft-versus-host disease
  • transfusion-induced immunosuppression

Averts exposure to new or unknown infectious or other noxious agents that might contaminate the blood supply

Reduces demand for banked allogeneic blood, thus can help alleviate blood shortages

Satisfies public demand and patients' desires that their own blood be used.

Blood loss must be anticipated and a program established to allow for blood predeposit or salvage

Does not prevent adverse effects such as

  • septicemia from bacterially contaminated unit
  • nonhemolytic transfusion reactions caused by plasma factors generated during blood storage
  • clerical or laboratory error leading to transfusion of the wrong unit
  • circulatory overload

Increased likelihood of receiving blood in the postoperative period

Cost is higher than with existing allogeneic program

Adds risk for adverse events associated with blood donation

Scheduling of surgery may have to be altered to permit autologous blood donation or to avoid wasting blood already collected

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| CMAJ June 1, 1997 (vol 156, no 11) / JAMC le 1er juin 1997 (vol 156, no 11) |
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