Five or more of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least 1 of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure
- Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., patient feels sad or empty) or observation made by others
- Markedly diminished interest or pleasure in all or almost all activities most of the day, nearly every day
- Significant weight loss when not dieting; weight gain; or decrease or increase in appetite nearly every day
- Insomnia or hypersomnia nearly every day
- Psychomotor agitation or retardation nearly every day
- Fatigue or loss of energy nearly every day
- Feelings of worthlessness or of excessive or inappropriate guilt nearly every day
- Diminished ability to think or concentrate, or indecisiveness, nearly every day
- Recurrent thoughts of death, recurrent suicidal ideation without a specific plan, suicide attempt or a specific plan for committing suicide
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