Fig. 1: Predicted survival curves for the long-term effects of simvastatin (solid line) compared with usual care (broken line) based on results from the Scandinavian Simvastatin Survival Study (4S study).[20,21] Survival curves for the simvastatin group were plotted according to 3 assumptions for the efficacy of the drug over the 10 years beyond the termination of the 4S study. Premise A = one-time clinical effect, premise B = semi-continuous clinical effect, premise C = continuous clinical effect (see Methods for details).

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