Pharmacologic treatment of hypertensive disorders in pregnancy

 

Table 1: Recommended criteria for deciding when to admit women with hypertension in pregnancy to hospital and when to start antihypertensive therapy*

Admission to hospital (grade D)

Mandatory

  • SBP > 169 mm Hg or DBP > 109 mm Hg or presenting with symptoms (epigastric pain, visual disturbance or severe headache)
Strongly recommended
  • Gestational hypertension with proteinuria, unless special outpatient care program is available
  • Pre-existing hypertension with superimposed gestational hypertension
  • Gestational, pre-existing or unclassified hypertension without proteinuria in women with DBP > 99 mm Hg
  • Pre-existing hypertension necessitating antihypertensive drug treatment and for which outpatient surveillance is impossible
Recommended
  • Gestational hypertension without proteinuria or unclassified hypertension with DBP 90-99 mm Hg in order to:
    • Obtain serial blood pressure readings
    • Exclude conditions associated with poor outcome
    • Assess fetal well-being

Transfer to tertiary care facility should be considered according to locally available neonatal care

Initiation of antihypertensive drug treatment

Immediately

  • SBP > 169 mm Hg or DBP > 109 mm Hg with symptoms (grade D)
After 1-2 hours of observation
  • SBP > 169 mm Hg or DBP > 109 mm Hg without symptoms (grade D)
After 24-48 hours of observation
  • SBP > 139 mm Hg or DBP > 89 mm Hg before 28 weeks' gestation in women with gestational hypertension without proteinuria (grade D) or in those with pre-existing hypertension (grade A)9
  • SBP > 139 mm Hg or DBP > 89 mm Hg any time in pregnancy in women with
    • gestational hypertension with symptoms (grade D),
    • gestational hypertension with proteinuria, (grade D)
    • pre-existing hypertension with underlying conditions (grade D),
    • pre-existing hypertension with target-organ damage (cardiovascular disease, renal impairment) (grade D), or
    • pre-existing hypertension with superimposed gestational hypertension (grade D)
  • SBP > 149 mm Hg or DBP > 94 mm Hg in other circumstances (grade D)
*These recommendations do not apply to women in labour. See Appendix 1 for definitions of the grades of recommendations. SBP = systolic blood pressure, DBP = diastolic blood pressure.

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| CMAJ November 1, 1997 (vol 157, no 9) / JAMC le 1er novembre 1997 (vol 157, no 9) |

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