Table 1: Summary of survival and recurrence in prospective randomized trials of mastectomy versus breast-conserving surgery
Study group	Interventions	No. of patients	Follow-up; yr	Survival; %	Disease-free survival; %	Local recurrence; %
Veronesi et al (Milan), 19907	BCS + RT TM	352 349	15 15	68 66	— —	3.3 2.3
Fisher et al (NSABP), 19893	BCS BCS + RT TM	636 629 590	8 8 8	83 84 82	64 71 67	39 10 8
Blichert-Toft et al (Denmark), 19922	BCS + RT TM	430 429	6 6	79 82	70 66	— —
van Dongen et al (EORTC), 19925	BCS + RT TM	426 456	8 8	60 60	— —	11 8
Jacobson et al (NCI), 19958	BCS + RT TM	121 116	10 10	77 75	72 69	5 10
Arriagada et al (Institut Gustave-Roussy), 19961	BCS + RT TM	88 91	15 15	73 65	55 44	9 14
NSABP = National Surgical Adjuvant Breast Project, NCI = National Cancer Institute, EORTC = European Organization for the Research and Treatment of Cancer, BCS = breast-conserving surgery, RT = radiotherapy, TM = total mastectomy Return to Guideline 3