Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis
| Appendix 1: Clinical trials comparing selective serotonin reuptake inhibitors with tricyclic antidepressants published between January 1980 and May 1996 and meeting the study criteria*† |
| Altamura AC, De Novellis F, Guercetti G, Invernizzi G, Percudani M, Montgomery SA. Fluoxetine compared with amitriptyline in elderly depression: a controlled clinical trial. Int J Clin Pharmacol Res 1989;9:391-6.
Amore M, Bellini M, Berardi D, Berlinzani L, Cervino G, Cremonini A, et al. Double-blind comparison of fluvoxamine and imipramine in depressed patients. Curr Ther Res 1989;46:815-20. Arminen SL, Ikonen U, Pulkkinen P, Leinonen E, Mahlanen A, Koponen H, et al. A 12-week double-blind multi-centre study of paroxetine and imipramine in hospitalized depressed patients. Acta Psychiatr Scand 1994;89:382-9.
Bascara L. A double-blind study to compare the effectiveness and tolerability of paroxetine and amitriptyline in depressed patients. Acta Psychiatr Scand 1989; Battegay R, Hager M, Rauchfleisch U. Double-blind comparative study of paroxetine and amitriptyline in depressed patients of a university psychiatric outpatient clinic (pilot study). Neuropsychobiology 1985;13:31-7. Beasley CM, Holman SL, Potvin JH. Fluoxetine compared with imipramine in the treatment of inpatient depression: a multicenter trial. Ann Clin Psychiatry 1993;5:199-207. Beasley CM, Sayler ME, Potvin JH. Fluoxetine versus amitriptyline in the treatment of major depression: a multicenter trial. Int Clin Psychopharmacol 1993;8:143-9. Bersani G, Rapisarda V, Ciani N, Bertolino A, Sorge G. A double-blind comparative study of sertraline and amitriptyline in outpatients with major depressive episodes. Hum Psychopharmacol 1994;9:63-8. Bignamini A, Rapisarda V, Italian Paroxetine Study Group. A double-blind multicentre study of paroxetine and amitriptyline in depressed outpatients. Int Clin Psychopharmacol 1992;6(Suppl 4):37-41. Bowden CL, Schatzberg, AF, Rosenbaum A, Contreras SA, Samson JA, Dessain E, et al. Fluoxetine and desipramine in major depressive disorder. J Clin Psychopharmacol 1993;13:305-10. Bramanti P, Ricci RM, Roncari R, Bilone F, Inga F, Teti V, et al. An Italian multicenter experience with fluvoxamine, a new antidepressant drug, versus imipramine. Curr Ther Res 1988;43:718-24. Bremner JD. Fluoxetine in depressed patients: a comparison with imipramine. J Clin Psychiatry 1984;45:414-9. Byerley WF, Reimherr FW, Wood DR, Grosser BI. Fluoxetine, a selective serotonin uptake inhibitor, for the treatment of outpatients with major depression. J Clin Psychopharmacol 1988;8:112-5. Byrne MM. Meta-analysis of early phase II studies with paroxetine in hospitalized depressed patients. Acta Psychiatr Scand 1989;80(Suppl 350):138-9. Chouinard G. A double-blind controlled clinical trial of fluoxetine and amitriptyline in the treatment of outpatients with major depressive disorder. J Clin Psychiatry 1985;46(3 Sec 2):32-7. Claghorn JL, Earl CQ, Walczak DD, Stoner KA, Wong LF, Kantner D, et al. Fluvoxamine maleate in the treatment of depression: a single-center, double-blind, placebo-controlled comparison with imipramine in outpatients. J Clin Psychopharmacol 1996;16:113-20. Cohn CK, Shrivastava R, Mendels J, Cohn JB, Fabre LF, Claghorn JL, et al. Double-blind multicenter comparison of sertraline and amitriptyline in elderly depressed patients. J Clin Psychiatry 1990;51(Suppl B):28-33. Cohn JB, Collins G, Ashbrook E, Wernicke JF. A comparison of fluoxetine, imipramine and placebo in patients with bipolar depressive disorder. Int Clin Psychopharmacol 1989;4:313-22. Cohn JB, Wilcox C. A comparison of fluoxetine, imipramine, and placebo in patients with major depressive disorder. J Clin Psychiatry 1985;46(3 Sec 2):26-31. Cohn JB, Wilcox CS. Paroxetine in major depression: a double-blind trial with imipramine and placebo. J Clin Psychiatry 1992;53(2 Suppl):52-6. Coleman BS, Block BA. Fluvoxamine maleate, a serotonergic antidepressant; a comparison with chlorimipramine. Prog Neuropsychopharmacol Biol Psychiatry 1982;6:475-8. Danish University Antidepressant Group. Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Disord 1990;18:289-99. De Jonghe F, Ravelli DP, Tuynman-Qua H. A randomized, double-blind study of fluoxetine and maprotiline in the treatment of major depression. Pharmacopsychiatry 1991;24:62-7. De Jonghe F, Swinkels J, Tuynman-Qua H. Randomized double-blind study of fluvoxamine and maprotiline in treatment of depression. Pharmacopsychiatry 1991;24:21-7. Dominguez RA, Goldstein BJ, Jacobson AF, Steinbook RM. A double-blind placebo-controlled study of fluvoxamine and imipramine in depression. J Clin Psychiatry 1985;46:84-7. Doogan DP, Langdon CJ. A double-blind, placebo-controlled comparison of sertraline and dothiepin in the treatment of major depression in general practice. Int Clin Psychopharmacol 1994;9:95-100. Dowling B, Webb MG, Halpin CM, Sangiwa MG. Fluoxetine: a comparative study with dothiepin. Ir J Psychiatry 1990;11:3-7. Dunbar GC, Cohn JB, Fabre LF, Feighner JP, Fieve RR, Mendels J, et al. A comparison of paroxetine, imipramine and placebo in depressed outpatients. Br J Psychiatry 1991;159:394-8. Dunner DL, Cohn JB, Walshe T, Cohn CK, Feighner JP, Fieve RR, et al. Two combined, multicenter double-blind studies of paroxetine and doxepin in geriatric patients with major depression. J Clin Psychiatry 1992;53(Suppl 2):57-60. Fabre LF. A 6-week, double-blind trial of paroxetine, imipramine, and placebo in depressed outpatients. J Clin Psychiatry 1992;53(2 Suppl):40-3. Fabre L, Birkhimer LJ, Zaborny BA, Wong LF, Kapik BM. Fluvoxamine versus imipramine and placebo: a double-blind comparison in depressed patients. Int Clin Psychopharmacol 1996;11:119-27. Fabre LF, Scharf MB, Itil TM. Comparative efficacy and safety of nortriptyline and fluoxetine in the treatment of major depression: a clinical study. J Clin Psychiatry 1991;52(6 Suppl):62-7. Fawcett J, Zajecka JM, Kravitz HM, Edwards J, Jeffriess H, Scorza E. Fluoxetine versus amitriptyline in adult outpatients with major depression. Curr Ther Res 1989;45:821-32. Feighner JP. A comparative trial of fluoxetine and amitriptyline in patients with major depressive disorder. J Clin Psychiatry 1985;46:369-72. Feighner JP, Boyer WF. Paroxetine in the treatment of depression: a comparison with imipramine and placebo. Acta Psychiatr Scand 1989;80(Suppl 350):125-9. Feighner JP, Boyer WF, Merideth CH, Hendrickson GG. A double-blind comparison of fluoxetine, imipramine and placebo in outpatients with major depression. Int Clin Psychopharmacol 1989;4:127-34. Feighner JP, Boyer WF, Meredith CH, Hendrickson GG. A placebo-controlled inpatient comparison of fluvoxamine maleate and imipramine in major depression. Int Clin Psychopharmacol 1989;4:239-44.
Feighner JP, Cohn JB. Double-blind comparative trials of fluoxetine and doxepin in geriatric patients with major depressive disorder. J Clin Psychiatr 1985; Feighner JP, Cohn JB, Fabre LF, Fieve RR, Mendels J, Shrivastava RK, et al. A study comparing paroxetine, placebo and imipramine in depressed patients. J Affect Disord 1993;28:71-9. Gasperini M, Gatti F, Bellini L, Anniverno R, Smeraldi R. Perspectives in clinical psychopharmacology of amitriptyline and fluvoxamine: a double-blind study in depressed inpatients. Neuropsychobiology 1992;26:186-92. Geretsegger C, Stuppaeck CH, Mair M, Platz T, Fartacek R, Heim M. Multicenter double blind study of paroxetine and amitryptyline in elderly depressed inpatients. Psychopharmacology 1995;119:277-81. Ginestet D. Fluoxetine in endogenous depression and melancholia versus clomipramine. Int Clin Psychopharmacol 1989;4(Suppl 1):37-40. Guelfi JD, Dreyfus JF, Pichot P. A double-blind controlled clinical trial comparing fluvoxamine with imipramine. Br J Clin Pharmacol 1983;15(Suppl 3):411S-417S. Guillibert E, Pelicier Y, Archambault JC, Chabannes JP, Clerc G, Desvilles M, et al. A double-blind, multicentre study of paroxetine versus clomipramine in depressed elderly patients. Acta Psychiatr Scand 1989;80(Suppl 350):132-4. Guy W, Wilson WH, Ban TA, King DL, Manov G, Fjetland OK. A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression. Psychopharmacol Bull 1984;20:73-8. Harris B, Szulecka TK, Anstee JA. Fluvoxamine versus amitriptyline in depressed hospital out-patients: a multicentre, double-blind, comparative trial. Br J Clin Res 1991;2:89-99. Hutchinson DR, Tong S, Moon CA, Vince M, Clarke A. Paroxetine in the treatment of elderly depressed patients in general practice: a double-blind comparison with amitriptyline. Int Clin Psychopharmacol 1992;6(Suppl 4):43-51. Itil TM, Shrivastava RK, Mukherjee S, Coleman BS, Michael ST. A double-blind placebo-controlled study of fluvoxamine and imipramine in out-patients with primary depression. Br J Clin Pharmacol 1983;15(Suppl 3):433S-438S. Judd FK, Moore K, Norman TR, Burrows GD, Gupta RK, Parker G. A multicentre double blind trial of fluoxetine versus amitriptyline in the treatment of depressive illness. Aust N Z J Psychiatry 1993;27:49-55. Keegan D, Bowen RC, Blackshaw S, Saleh S, Dayal N, Remillard F, et al. A comparison of fluoxetine and amitriptyline in the treatment of major depression. Int Clin Psychopharmacol 1991;6:117-24.
Kuha S, Mehtonen OP, Henttonen A, Naarala M. The efficacy of fluoxetine versus maprotiline in depressed patients and by dose. Nord Psykiatr Tidsskr 1991; Kuhs H, Rudolf GA. A double-blind study of the comparative antidepressant effect of paroxetine and amitriptyline. Acta Psychiatr Scand 1989;80(Suppl 350):145-6. Laakmann G, Blaschke D, Engel R, Schwarz A. Fluoxetine vs amitriptyline in the treatment of depressed out-patients. Br J Psychiatry 1988;153(Suppl 3):64-8. Lapierre YD, Browne M, Horn E, Oyewumi LK, Sarantidis D, Roberts N, et al. Treatment of major affective disorder with fluvoxamine. J Clin Psychiatry 1987;48:65-8. Laursen AL, Mikkelsen PL, Rasmussen S, le Fèvre Honoré P. Paroxetine in the treatment of depression: a randomized comparison with amitriptyline. Acta Psychiatr Scand 1985;71:249-55. Levine S, Deo R, Mahadevan K. A comparative trial of a new antidepressant, fluoxetine. Int Clin Psychopharmacol 1989;4(Suppl 1):41-5. Lydiard RB, Laird LK, Morton WA, Steele TE, Kellner C, Laraia MT, et al. Fluvoxamine, imipramine, and placebo in the treatment of depressed outpatients: effects on depression. Psychopharmacol Bull 1989;25(1):68-70. Möller HJ, Berzewski H, Eckmann F, Gonzalves N, Kissling W, Knorr W, et al. Double-blind multicenter study of paroxetine and amitriptyline in depressed inpatients. Pharmacopsychiatry 1993;26:75-8. Moon CA, Jago W, Wood K, Doogan DP. A double-blind comparison of sertraline and clomipramine in the treatment of major depressive disorder and associated anxiety in general practice. J Psychopharmacol 1994;8:171-6. Moon C, Vince M. Treatment of major depression in general practice: a double-blind comparison of paroxetine and lofepramine. Br J Clin Pract 1996;50:240-4. Mullin JM, Pandita-Gunawardena VR, Whitehead AM. A double-blind comparison of fluvoxamine and dothiepin in the treatment of major affective disorder. Br J Clin Pract 1988;42:51-5. Nathan RS, Perel JM, Pollock BG, Kupfer DJ. The role of neuropharmacologic selectivity in antidepressant action: fluvoxamine versus desipramine. J Clin Psychiatry 1990;51:367-72. Nielsen BM, Behnke K, Arup P, Christiansen PE, Geisler A, Ipsen E, et al. A comparison of fluoxetine and imipramine in the treatment of outpatients with major depressive disorder. Acta Psychiatr Scand 1993;87:269-72. Nielsen OA, Morsing I, Petersen JS, Larsen T, Moller SE, Manniche PM, et al. Paroxetine and imipramine treatment of depressive patients in a controlled multicentre study with plasma amino acid measurements. Acta Psychiatr Scand 1991;84:233-41. Noguera R, Altuna R, Alvarez E, Ayuso JL, Casais L, Udina C. Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial. J Affect Disord 1991;22:119-24. Nolen WA, van de Putte JJ, Dijken WA, Kamp JS, Blansjaar BA, Kramer HJ, et al. Treatment strategy in depression: 1. Non-tricyclic and selective reuptake inhibitors in resistant depression: a double-blind partial crossover study on the effects of oxaprotiline and fluvoxamine. Acta Psychiatr Scand 1988;78:668-75. Norton KR, Sireling LI, Bhat AV, Rao B, Paykel ES. A double-blind comparison of fluvoxamine, imipramine and placebo in depressed patients. J Affect Disord 1984;7:297-308. Ohrberg S, Christiansen PE, Severin B, Calberg H, Nilakantan B, Borup A, et al. Paroxetine and imipramine in the treatment of depressive patients in psychiatric practice. Acta Psychiatr Scand 1992;86:437-44. Pélicier Y, Schaeffer P. Étude multicentrique en double aveugle comparant l'efficacité et la tolérance de la paroxétine et de la clomipramine dans la dépression réactionnelle du sujet âgé [A multi-centre, double-blind study to compare the efficacy and tolerability of paroxetine and clomipramine in elderly patients with reactive depression]. Encephale 1993;19:257-61. Peselow ED, Filippi AM, Goodnick P, Barouche F, Fieve RR. The short- and long-term efficacy of paroxetine HCI: a. Data from a 6-week double-blind parallel design trial vs. imipramine and placebo. Psychopharmacol Bull 1989;25:267-71. Poelinger W, Haber H. Fluoxetine 40mg vs maprotiline 75mg in the treatment of out-patients with depressive disorders. Int Clin Psychopharmacol 1989; 4(Suppl 1):47-50. Reimherr FW, Byerley WF, Ward MF, Lebegue BJ, Wender PH. Sertraline, a selective inhibitor of serotonin uptake, for the treatment of outpatients with major depressive disorder. Psychopharmacol Bull 1988;24:200-5. Reimherr FW, Chouinard G, Cohn CK, Cole JO, Itil TM, Lapierre YD, et al. Anti-depressant efficacy of sertraline: a double-blind, placebo- and amitriptyline-controlled, multicenter comparison study in outpatients with major depression. J Clin Psychiatry 1990;51(12 Suppl B):18-27. Remick RA, Claman J, Reesal R, Gibson RE, Agbayewa MO, Lam RW, et al. Comparison of fluoxetine and desipramine in depressed outpatients. Curr Ther Res 1993;53:457-65. Remick RA, Keller FD, Gibson RE, Carter D. A comparison between fluoxetine and doxepin in depressed patients. Curr Ther Res 1989;46:842-8. Remick RA, Reesal R, Oakander M, Allen J, Claman J, Ramirez CE, et al. Comparison of fluvoxamine and amitriptyline in depressed outpatients. Curr Ther Res 1994;55:243-50. Robertson MM, Abou-Saleh MT, Harrison DA, Nairac BL, Edwards DR, Lock T, et al. A double-blind controlled comparison of fluoxetine and lofepramine in major depressive illness. J Psychopharmacol 1994;8:98-103. Ropert R. Fluoxetine versus clomipramine in major depressive disorders. Int Clin Psychopharmacol 1989;4(Suppl 1):89-95. Shrivastava RK, Shrivastava SH, Overweg N, Blumhardt CL. A double-blind comparison of paroxetine, imipramine, and placebo in major depression. J Clin Psychiatry 1992;53(2 Suppl):48-51. South Wales Antidepressant Drug Trial Group. A double-blind multi-centre trial of fluoxetine and dothiepin in major depressive illness. Int Clin Psychopharmacol 1988;3:75-81. Staner L, Kerkhofs M, Detroux D, Leyman S, Linkowski P, Mendlewicz J. Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression. Sleep 1995;18:470-7. Stark P, Hardison CD. A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder. J Clin Psychiatry 1985; 46(3 Sec 2):53-8. Tamminen TT, Lehtinen VV. A double-blind parallel study to compare fluoxetine with doxepin in the treatment of major depressive disorders. Int Clin Psychopharmacol 1989;4(Suppl 1):51-6. Young JP, Coleman A, Lader MH. A controlled comparison of fluoxetine and amitriptyline in depressed out-patients. Br J Psychiatry 1987;151:337-40. |
| *Listed in alphabetical order according to first author's surname. †See reference 6 for details on individual trial estimates. |
