Canadian Immunization Guide 2006
Table 1. Type and Contents of Vaccines Currently Approved for Use in Canada
(May 2006)
| Brand name | Mfr/ distr. |
Route | Vaccine type | Adjuvant | Preservative | Potentiel allergens (egg, antibiotic, gelatin, latex, trace of thimerosal) | Other materials | ||
|---|---|---|---|---|---|---|---|---|---|
| Vaccine type | Immunogen+ | Products | |||||||
| Act-HIB® | SP | IM | Subunit | Hib | Conjugate | ||||
| Actacel™* | SP | IM | Subunit | D, T, aP + (Hib) | Proteins + conjugate | Alum | PE | ||
| Adacel® | SP | IM | Subunit | T, d, ap | Proteins | Alum | PE | ||
| Avaxim® | SP | IM | Inactivated | HA | Killed virus | Alum | PE | Neomycin | Formaldehyde |
| Avaxim® - Pediatric | SP | IM | Inactivated | HA | Killed virus | Alum | PE | Neomycin | Formaldehyde |
| BCG Vaccine (Freeze-Dried) | SP | Intra-dermal | Live attenuated | BCG | Live bacteria | Polysorbate 80 | |||
| Boostrix®* | GSK | IM | Subunit | D, T, aP | Proteins | Alum | PE | Formaldehyde | |
| DT Polio Adsorbed | SP | IM | Subunit + inactivated | D, T, IPV | Proteins + killed virus | Alum | PE | Polymyxin B, Neomycin | Formaldehyde |
| Dukoral™ | SBL/SP | Oral | Subunit + inactivated | Chol-Ecol-O | Proteins + killed bacteria | Saccharin | |||
| Multi dose vial Engerix®-B Single dose vial | GSK | IM | Subunit | HB | Recombinant protein | Alum | PE | Trace thimerosal | Yeast proteins |
| None | |||||||||
| Eolarix™* | GSK | SC | Live | M,R | Live virus | Neomycin | Human albumin Lactose, Dextran | ||
| Epaxal®** | BERN | IM | Inactivated | HA in Inf virosome | Killed virus | Tm | Formaldehyde | ||
| Fluviral® S/F | IDB | IM | Inactivated | Inf | Killed virus | Tm | Egg proteins | Formaldehyde | |
| FSME - IMMUN | BAX | IM | Inactivated | TBE | Inactivated whole virus | Alum | Neomycin Gentamycin Egg Protamine sulfate Chick protein |
Formaldehyde Human serum albumin Sucrose | |
| Havrix® | GSK | IM | Inactivated | HA | Killed virus | Alum | PE | Neomycin Latex in stopper pre-filled syringes |
Formaldehyde Polysorbate 20 |
| Hiberix®* | GSK | IM | Subunit | Hib | Conjugate | Lactose | |||
| Imovax® Polio* | SP | SC | Inactivated | IPV | Killed virus | PE | Polymyxin B Neomycin, Streptomycin |
Bovine serum Formaldehyde Polysorbate 80 | |
| Imovax® Rabies | SP | IM | Inactivated | Rab | Killed virus | Neomycin | Human albumin | ||
| Inactived Poliomyelitis Vaccine – IPV | SP | SC | Inactivated | IPV | Killed virus | PE | Polymyxin B Neomycin |
Bovine serum Formaldehyde Polysorbate 80 | |
| Infanrix™* | GSK | IM | Subunit | D, T, aP | Proteins | Alum | PE | Formaldehyde Polysorbate 80 | |
| Infanrix™-hexa* | GSK | IM | Subunit + inactivated | D, T, aP, HB IPV + (Hib) | Proteins + killed viruses + conjugate | Alum | PE | Polymyxin B Neomycin Trace thimerosal |
Yeast protein Formaldehyde Lactose Polysorbate 20 and 80 Bovine serum albumin |
| Infanrix™/Hib* | GSK | IM | Subunit | D, T, aP + (Hib) | Proteins + conjugate | Alum | PE | Formaldehyde Lactose Polysorbate 80 |
|
| Infanrix™-IPV* | GSK | IM | Subunit + inactivated | D, T, aP IPV | Proteins + killed virus | Alum | PE | Polymyxin B Neomycin |
Bovine serum Formaldehyde Polysorbate 80 |
| Infanrix™- IPV/Hib* | GSK | IM | Subunit + inactivated | D, T, aP, IPV + (Hib) | Protein + killed virus + conjugate | Alum | PE | Polymyxin B Neomycin |
Formaldehyde Polysorbate 80 Lactose Bovine serum albumin |
| Influvac™ | SOLV | IM/SC | Inactivated | Inf | Killed virus | Gentamicin Egg protein |
Chicken protein Formaldehyde Polysorbate 80 | ||
| JE-VAX® | BIKEN/ SP | SC | Inactivated | JE | Killed virus | Tm | Gelatin | Mouse serum Protein Formaldehyde | |
| Liquid Pedvax HIB® | MF | IM | Subunit | Hib | Conjugate | Alum | Latex in stopper | ||
| Meningitec™ | BERN/ WA | IM | Subunit | Men | Conjugate | Alum | |||
| Meningococcal Polysaccharide Vaccine, Groups A and C, Menomune® A/C |
SP | SC | Subunit | Men | Polysaccharide | Lactose | |||
| Menjugate® | CHIR | IM | Subunit | Men | Conjugate | Alum | |||
| Multidose vial Menomune® A/C/Y/W-135 Single dose vial | SP | SC | Subunit | Men | Polysaccharide | Tm† | Latex in stopper | Lactose | |
| None | |||||||||
| M-M-R® II | MF | SC | Live | M, M, R | Live virus | Gelatine Neomycin Residual components of chick embryo cell cultures | Bovine Serum Glutamate Human albumin Residual protein from cell culture Sorbitol Sucrose | ||
| Mutacol™** | BERN | Oral | Live | Chol | Live bacteria | Yeast extract Lactose Aspartame | |||
| Neisvac-C™ | BAX/ GSK | IM | Subunit | Men | Conjugate | Alum | |||
| Pediacel®* | SP | IM | Subunit + inactivated | D, T, aP, IPV, Hib | Protein, killed virus + conjugate | Alum | PE | Neomycin Polymyxin B Streptomycin Latex in stopper |
Bovine serum Formaldehyde Polysorbate 80 |
| Pediarix™* | GSK | IM | Subunit + inactivated | D, T, aP, HB, IPV | Protein + killed virus | Alum | PE | Polymyxin B Neomycin |
Yeast protein Formaldehyde Polysorbate 80 Bovine serum albumin |
| Pentacel® | SP | IM | Subunit + inactivated | D, T, aP, IPV + (Hib) | Protein + killed virus + (conjugate) | Alum | PE | Polymyxin B Neomycin Latex in stopper |
Bovine albumin Formaldehyde Polysorbate 80 |
| Pneumo 23® | SP | IM/SC | Subunit | Pneu | Polysaccharide | P | |||
Multidose vial*
Pneumovax® 23 |
MF | IM/SC | Subunit | Pneu | Polysaccharide | P | |||
| Prevnar® | WA | IM | Subunit | Pneu | Conjugate | Alum | Latex in stopper | ||
| Priorix® | GSK | SC | Live | M, M, R | Live virus | Neomycin | Lactose | ||
| Quadracel® | SP | IM | Subunit + inactivated | D, T, aP, IPV | Protein + killed virus | Alum | PE | Polymyxin B Neomycin Latex in stopper |
Bovine albumin Formaldehyde Polysorbate 80 |
| RabAvert® | CHIR/ MF | IM | Inactivated | Rab | Killed virus | Neomycin Chlortetracycline Amphotericin B Processed gelatin |
Human albumin Ovalbumin Bovine serum | ||
| Multidose vial
Recombivax HB® Single dose vials |
MF | IM | Subunit | HB | Recombinant protein | Alum | Tm† | Latex in stopper | Yeast proteins Formaldehyde |
| None | |||||||||
| Td Adsorbed | SP | IM | Subunit | T, d | Protein | Alum | Formaldehyde | ||
| Td Polio Adsorbed | SP | IM | Subunit + inactivated | T, d, IPV | Protein + killed virus | Alum | PE | Polymyxin B Neomycin |
Bovine albumin Formaldehyde Polysorbate 80 |
| Tetanus Toxoid Adsorbed | SP | IM | Subunit | T | Protein | Alum | Tm | ||
| Tripacel® | SP | IM | Subunit | D, T, aP | Protein | Alum | PE | Latex in stopper | Formaldehyde Glutaraldehyde |
| Twinrix® | GSK | IM | Subunit + inactivated | HB, HA | Recombinant protein + killed virus | PE | Neomycin Trace thimerosal Latex in stopper pre-filled syringes |
Yeast proteins Formaldehyde Polysorbate 20 | |
| Twinrix® Junior | GSK | IM | Subunit + inactivated | HB, HA | Recombinant protein + killed virus | PE | Neomycin Trace thimerosal Latex in stopper pre-filled syringes |
Yeast proteins Formaldehyde Polysorbate 20 | |
| Typherix® | GSK | IM | Subunit | Typh-l | Polysaccharide | P | Latex in stopper pre-filled syringes | ||
| Typhim Vi® | SP | IM | Subunit | Typh-l | Polysaccharide | P | |||
| Vaqta® | MF | IM | Inactivated | HA | Killed virus | Alum | Neomycin Latex in stopper |
Bovine albumin Formaldehyde Residual protein from cell culture | |
| Varilrix® | GSK | SC | Live | Var | Live virus | Neomycin Latex in stopper pre-filled syringes for diluent |
Human albumin Lactose |
||
| Varivax® III | MF | SC | Live | Var | Live virus | Gelatin Neomycin |
Bovine serum
Glutamate
Residual protein
from cell culture Sucrose Urea |
||
| Multidose vial Vaxigrip® Single dose vial | SP | IM | Inactivated | Inf | Killed virus | Tm† | Neomycin Egg protein |
Formaldehyde | |
| ViVaxim™ | SP | IM | Subunit + inactivated | Typh-I + (HA) | Polysaccharide + killed virus | Alum | PE | Neomycin | Formaldehyde |
| Vivotif® L | BERN | Oral | Live | Typh-O | Live virus | Lactose Aspartame | |||
| Vivotif® | BERN | Oral | Live | Typh-I | Live virus | Gelatin | Lactose | ||
| YF-VAX® | SP | SC | Live | YF | Live virus | Gelatin Egg protein Latex in stopper |
Chicken protein | ||
Empty boxes indicate a lack of the specified component.
* Drug Identification Number assigned (approved for use but not currently marketed)
** Product is on the market but not currently available
† Thimerosal in multidose vial only
Notes and Abbreviations
The information in this table is based on the product’s availability as of May 2006. Please consult the manufacturer for complete and up-to-date information. The National Advisory Committee on Immunization (NACI) will publish updated information as required, which will be available at www.naci.gc.ca.
Manufacturer (Mfr) and Distributor (Distr.): For some products, the distributor could be different from the manufacturer.
BAX, Baxter Healthcare Corporation; BERN, Berna Biotech; BIKEN, Biken; CHIR, Chiron; GSK, GlaxoSmithKline; IDB, ID Biomedical Corporation; MF, Merck Frosst; SBL, SBL Vaccine; SP,
Sanofi Pasteur Ltd; SOLV, Solvay; WA, Wyeth Canada
Route: IM - intramuscular; SC - subcutaneous
Immunogen:
+ For products in which the immunogens of two different vials or chambers are combined, the contents of the second vial or chamber are noted as + (immunogen)
The following abbreviations are the agreed upon standards for use in Canada:
DTaP-IPV-Hib: diphtheria toxoid, tetanus toxoid, acellular pertussis, polio, Haemophilus influenzae type b, pediatric formulation; Tdap: tetanus toxoid, diphtheria toxoid, acellular
pertussis, adult formulation; Men - meningococcus; Pneu - pneumococcus; HB: hepatitis B; Chol-Ecol-O: cholera - E.coli
IPV - poliomyelitis vaccine; Inf: influenza; HA: hepatitis A; Rab: rabies; JE: Japanese encephalitis; Typh-I : typhoid - injection; Typh-O: Typhoid - Oral; TBE; tickborne encephalitis
MMR: measles, mumps, rubella; Var: varicella; YF: yellow fever; BCG: Bacilles Calmette-Guérin
Adjuvant: Alum - aluminum-containing adjuvant
Preservative:
P - phenol; PE - 2 phenoxy ethanol; Tm - thimerosal. For the Sanofi Pasteur products, PE is not considered a preservative