Glucose toxicity: the implications of hyperglycemia in the
pathophysiology of diabetes mellitus
Luciano Rossetti
Division of Endocrinology, Department of Medicine, Diabetes
Research Center, Albert Einstein College of Medicine of Yeshiva
University, Bronx, New York, USA
Abstract
Non-insulin-dependent diabetes mellitus (NIDDM) results from a
disruption of normal glucose homeostasis, primarily insulin
secretion and hepatic and peripheral insulin action. However,
chronic hyperglycemia has been shown in animal models to
contribute to impaired insulin secretion as well as to peripheral
insulin resistance. Consequently, stringent control measures aimed
at ameliorating chronically elevated blood glucose levels may help
lessen the cellular "toxic" effect of hyperglycemia.
Clin Invest Med 1995; 18 (4): 255-260
Table of contents: CIM vol. 18, no. 4
Copyright 1996 Canadian Medical Association