Improving the action of insulin
Pierre J. Lefèbvre
André J. Scheen
Division of Diabetes, Nutrition and Metabolic
Disorders, Department of Medicine, University of
Liège, Belgium
Copyright 1996 Canadian Medical Association
Abstract
Improving the action of insulin is a relatively new concept in
diabetes management. Insulin sensitivity can be improved by
reduction of excessive body weight, regular physical activity and,
possibly, by correcting a subclinical magnesium deficiency.
Pharmacological means of improving insulin action include
metformin, antiobesity serotoninergic agents and, possibly,
benfluorex. New compounds aiming at improving the action of
insulin are in development and include thiazolidinedione derivatives
(known as "insulin sensitizers"), inhibitors of adipose tissue
lipolysis (e.g., acipimox), and inhibitors of free fatty acid oxidation
(e.g., etomoxir). Avoidance of drugs that reduce insulin sensitivity,
such as beta blockers and thiazide diuretics, is recommended.
Finally, cigarette smoking is associated with resistance to insulin
but it remains to be demonstrated that cessation of cigarette
smoking does in fact increase sensitivity to insulin.
Clin Invest Med 1995; 18 (4): 340-347
Table of contents: CIM vol. 18, no. 4