Table 1: Is CreutzfeldtJakob disease transmitted in blood? / CMAJ

Is CreutzfeldtJakob disease transmitted in blood?

Table 1: Route of infection, number of patients, entry route and incubation for transmissible Creutzfeld–Jakob disease*

Mode of infection Number of patients Agent entry into brain Mean incubation period (range)

Instrumentation

Neurosurgery 4 Intracerebral 20 mo (15–28)

Stereotactic EEG 2 Intracerebral 18 mo (16, 20)

Tissue transfer

Corneal transplant 1† Optic nerve 18 mo

Dura mater implant 68† Cerebral surface 5.5 yr (1.5–12)‡

Tissue extract transfer

Growth hormone 76 Hematogenous 12 yr (5–30)

Gonadotrophin 4 Hematogenous 13 yr (12–16)

*Adapted with permission from Brown.⁹
†Number of cases updated from original to reflect new information.
‡Incubation period based on data for 25 patients.

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| CMAJ November 15, 1997 (vol 157, no 10) / JAMC le 15 novembre 1997 (vol 157, no 10) |

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Table 1: Route of infection, number of patients, entry route and incubation for transmissible Creutzfeld–Jakob disease*
Mode of infection	Number of patients	Agent entry into brain	Mean incubation period (range)
Instrumentation
Neurosurgery	4	Intracerebral	20 mo	(15–28)
Stereotactic EEG	2	Intracerebral	18 mo	(16, 20)
Tissue transfer
Corneal transplant	1†	Optic nerve	18 mo
Dura mater implant	68†	Cerebral surface	5.5 yr	(1.5–12)‡
Tissue extract transfer
Growth hormone	76	Hematogenous	12 yr	(5–30)
Gonadotrophin	4	Hematogenous	13 yr	(12–16)
*Adapted with permission from Brown.⁹ †Number of cases updated from original to reflect new information. ‡Incubation period based on data for 25 patients.