Nonvalvular atrial fibrillation: evidence for a prothrombotic state

 

Table 5: Hemostatic markers unaffected by warfarin in NVAF patients with a history of an embolic event and control subjects with a history of thrombotic stroke
VariableGroup; mean value (and SD) Difference in means (and 95% CI) Adjusted value*
NVAF patients with history of event n = 25 Control subjects with history of stroke n = 11
Hemoglobin, g/L141  (12) 143  (17) -2  (-13, 9)0.48
Platelet count, × 109/L 253  (82) 242  (77)11  (-45, 66) 0.94
Fibrinogen, g/L3.8  (0.9) 4.0  (0.9) -0.2  (-0.8, 0.4) 0.28
Von Willebrand factor antigen, µ/mL 2.1  (0.6) 2.3  (1.2)-0.2  (-0.9, 0.5) 0.12
Factor VIII, µ/mL 1.6  (0.5)1.7  (0.7) -0.1  (-0.6, 0.4) 0.08
Fibrin D­dimer, % of subjects with level < 200, 200-500 and > 500 ng/mL respectively 92, 4, 494, 4, 2 -- 
Antithrombin III, µ/mL 1.00  (0.14) 1.00  (0.13) 0  (-0.09, 0.09) 0.74
*Determined by ANOVA, for difference between groups after adjustment for age and sex.

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| CMAJ September 15, 1997 (vol 157, no 6) / JAMC le 15 septembre 1997 (vol 157, no 6) |

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