Nonvalvular atrial fibrillation: evidence for a prothrombotic state

 

Table 6: Hemostatic markers in control subjects
MarkerControl group; mean value (and SD) Difference in means (and 95% CI) Adjusted value*
With history of stroke n = 11 Without history of stroke n = 31
Fibrinogen, g/L4.0  (0.9) 3.2  (1.1) 0.8  (0.16, 1.43) 0.04
Von Willebrand factor antigen, µ/mL 2.3  (1.2) 1.5  (0.6)0.8  (0.06, 1.53) 0.002
Factor VIII, µ/mL 1.7  (0.7)1.3  (0.3) 0.4  ( 0.05, 0.85) 0.002
Protein C, µ/mL 0.91  (0.23) 1.10  (0.24) 0.19  ( 0.35, 0.03) 0.08
Protein S, µ/mL 0.86  (0.09) 0.98  (0.17) 0.12  ( 0.20, 0.04) 0.023
Prothrombin fragment
F1+2, nmol/L
   All subjects 1.5  (1.43) 1.8  (0.99)0.30  ( 1.20, 0.60) 0.46
   Excluding outliers† 1.04  (0.27) 1.72  (0.97) 0.68  ( 1.10, 0.30) 0.06
 n = 7 n = 29   
*Determined by ANOVA, for difference between groups after adjustment for age and sex.
†As described in Table 4.

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| CMAJ September 15, 1997 (vol 157, no 6) / JAMC le 15 septembre 1997 (vol 157, no 6) |

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