Fig. 1: Median plasma tissue plasminogen activator (tPA) levels (boxes) and interquartile ranges (vertical rules) in patients with nonvalvular atrial fibrillation (NVAF) and control subjects in sinus rhythm with and without a history of thrombotic stroke. NVAF 1 = patients with no prior embolic event (transient ischaemic attack or embolic stroke) and not taking warfarin, NVAF 2 = patients with no prior embolic event and taking warfarin, NVAF 3 = patients with prior embolic event and taking warfarin. Horizontal rule across the middle of the graph denotes laboratory upper limit of normal for tPA levels (11.7 ng/mL).