Alzheimer's disease: current knowledge, management and research

 

Table 1: Diagnostic criteria of Alzheimer's disease20
Development of multiple cognitive deficits manifested by both:
  • Memory impairment (impaired ability to learn new information or to recall previously learned information)
  • One or more of aphasia, apraxia, agnosia or disturbance in executive functioning.
Substantial impairment of social or occupational functioning and significant decline from prior level of functioning caused by these cognitive deficits
Gradual onset and continuing cognitive decline, not occurring exclusively during the course of delirium and not better accounted for by a primary psychiatric disorder such as major depression or schizophrenia
Development of cognitive deficits not due to :
  • Other central nervous system conditions that cause progressive deficits in memory and cognition (e.g., stroke, Parkinson's disease, subdural hematoma, normal-pressure hydrocephalus or brain tumour)
  • Systemic conditions that can cause dementia (e.g., hypothyroidism, vitamin B12 or folic acid deficiency, neurosyphilis, HIV infection)
  • Condition induced by substance abuse (e.g., alcohol or sedatives)

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| CMAJ October 15, 1997 (vol 157, no 8) / JAMC le 15 octobre 1997 (vol 157, no 8) |

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