Table 3: Pharmacologic treatment of depression in late life / [CMAJ

Pharmacologic treatment of depression in late life

Table 3: Inhibitory effect of selective serotonin reuptake inhibitors (SSRIs) on P-450 isoenzymes*

SSRI Isoenzyme†

1A2 2C 2D6 3A4

Fluoxetine/norfluoxetine + ++ +++ ++

Fluvoxamine +++ ++ + ++

Paroxetine + + +++ +

Sertraline + ++ ++ ++

*Based on currently available in vitro and in vivo data.^29,31,32
†Potency of inhibition: + = mild; ++ = moderate; +++ = strong. A rating of ++ or higher is usually necessary for the inhibition to have clinical significance.

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| CMAJ October 15, 1997 (vol 157, no 8) / JAMC le 15 octobre 1997 (vol 157, no 8) |

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Table 3: Inhibitory effect of selective serotonin reuptake inhibitors (SSRIs) on P-450 isoenzymes*
SSRI	Isoenzyme†
SSRI	1A2	2C	2D6	3A4
Fluoxetine/norfluoxetine	+	++	+++	++
Fluvoxamine	+++	++	+	++
Paroxetine	+	+	+++	+
Sertraline	+	++	++	++
*Based on currently available in vitro and in vivo data.^29,31,32 †Potency of inhibition: + = mild; ++ = moderate; +++ = strong. A rating of ++ or higher is usually necessary for the inhibition to have clinical significance.