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HIV-1 Strain and Primary Drug Resistance in Canada
Surveillance Report to June 30, 2001
Appendix 2
List of primary mutations used for this report
|
Protease |
|
|
Primary mutation |
Anti-retroviral drug |
|
D30N |
Nelfinavir |
|
M46I |
Ritonavir |
|
M46L |
Indinavir |
|
I47V |
Amprenavir |
|
G48V |
Saquinavir |
|
I50V |
Amprenavir |
|
V82A/F/S/T |
Indinavir, ritonavir |
|
I84V |
Amprenavir |
|
N88D |
Nelfinavir |
|
L90M |
Nelfinavir |
|
Reverse transcriptase |
|
|
Primary mutation |
Anti-retroviral drug |
|
M41L |
AZT |
|
I50V |
d4T |
|
K65R |
Adefovir |
|
T69D/N |
ddC |
|
K70E |
Adefovir |
|
K70R |
AZT |
|
L74V |
ddI, ddC, abacavir |
|
V75T |
d4T |
|
K103T |
Delavirdine |
|
K103N |
Delavirdine, efavirenz, nevirapine |
|
V106A |
Nevirapine |
|
Q151M |
AZT, ddI, ddC, d4T, 3TC, FTC, abacavir |
|
Q161L |
Foscarnet |
|
Y181C/I/L |
Delavirdine, efavirenz, nevirapine |
|
M184I/V |
3TC, FTC, abacavir, adefovir |
|
G190A/E/S |
Nevirapine |
|
H208Y |
Foscarnet |
|
T215F/Y |
AZT |
1. Note: The correlation of drug resistance to genotype in this report is based on scientific consensus of primary mutations associated with HIV resistance to anti-retroviral drugs as of June 2001. These correlations do not necessarily imply phenotypic resistance to a particular anti-retroviral drug in a clinical setting.
