Botulism

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Nationally notifiable since 1933, 1940 onward

1.0 National Notification

Only confirmed cases of disease should be notified.

2.0 Type of Surveillance

Routine case-by-case notification to the federal level.

3.0 Case Classification

3.1 Confirmed case

A confirmed case requires laboratory definitive evidence with clinical evidence or, in the case of foodborne botulism, clinical evidence and consumption of the same suspect food as an individual who has laboratory-confirmed botulism.

Foodborne Botulism (Either 1 or 2)

1. Laboratory confirmation of intoxication with clinical evidence:
   detection of botulinum toxin in serum, stool, gastric aspirate or food
   OR
   isolation of Clostridium botulinum from stool or gastric aspirate
2. Clinical evidence and indication that the client ate the same suspect food as an individual with laboratory-confirmed botulism

Wound Botulism

Laboratory confirmation of infection: laboratory detection of botulinum toxin in serum
OR
isolation of C. botulinum from a wound
AND
presence of a freshly infected wound in the 2 weeks before symptoms and no evidence of consumption of food contaminated with C. botulinum

Infant Botulism

Laboratory confirmation with symptoms compatible with botulism in a person less than one year of age:
detection of botulinum toxin in stool or serum
OR
isolation of C. botulinum from the patient’s stool or at autopsy

Colonization Botulism

Laboratory confirmation with symptoms compatible with botulism in a patient aged 1 year or older with severely compromised gastrointestinal tract functioning (i.e. abnormal bowel) due to various diseases, such as colitis, or intestinal bypass procedures, or in association with other conditions that may create local or widespread disruption in the normal intestinal flora:
detection of botulinum toxin in stool or serum
OR
isolation of C. botulinum from the patient’s stool or at autopsy

3.2 Probable case

Foodborne

A probable case requires clinical evidence and consumption of a suspect food item in the incubation period (12-48 hours).

4.0 Laboratory Evidence

4.1 Laboratory Confirmation(from CPHLN document)

Any of the following will constitute a case of botulism:

Detection of botulinum toxin, with or without culture

Isolation of C. botulinum

4.2 Approved/Validated Tests

Standard culture for C. botulinum with demonstration of neurotoxin

C. botulinum neurotoxin mouse bioassay

4.3 Indications and limitations

In wound and foodborne botulism C. botulinum neurotoxin may not be detectable in serum. Administration of antitoxin prior to withdrawal of blood will result in a negative assay.

While some strains of C. botulinum type C may not produce neurotoxin, two other species of the genus, C. baratii and C. butyricum may produce the neurotoxin.

Culture without toxin assay by mouse bioassay is not useful. Group I C. botulinum cannot be distinguished from C. sporogenes without toxin assay.

Isolates and/or clinical specimens should be referred to the National Botulism Reference Service or the British Columbia Centre for Disease Control

EIA for botulinum toxin is not as sensitive as the mouse bioassay and therefore should not replace the mouse bioassay for neurotoxin detection in clinical specimens; however, EIA could be used to detect neurotoxin production from cultures.

5.0 Clinical Evidence

Foodborne: Clinical illness is characterized by blurred vision, dry mouth and difficulty swallowing and speaking. Descending and symmetric paralysis may progress rapidly, often requiring respiratory support.

Wound: Clinical illness is characterized by diplopia, blurred vision and bulbar weakness. Symmetric paralysis may progress rapidly.

Infant: Clinical illness in infants is characterized by constipation, loss of appetite, weakness, altered cry and loss of head control

6.0 ICD Code(s)

6.1 ICD-10 Code(s)

A05.1

Botulism (Classical foodborne intoxication due to Clostridium botulinum)

6.2 ICD-9/ICD-9CM Code(s)

005.1

Botulism

7.0 Type of International Reporting

Reportable to WHO under International Health Regulations

8.0 Comments

One case is considered an outbreak. Probable case definitions are provided as guidelines to assist with case finding and public health management, and are not for national notification purposes.

9.0 References

Protocol under development (Centre for Food-borne, Enteric and Zoonotic Infectious Diseases

CDC Notifiable Disease Case Definitions Taillac PP, Kim J. CBRNE-Botulism. Last updated June 2006. Available at:http://www.emedicine.com/emerg/topic64.htm

Date of Last Revision/Review:

November 2008