Hantavirus Pulmonary Syndrome

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Nationally notifiable since 2000

1.0 National Notification

Only confirmed cases of disease should be notified.

2.0 Type of Surveillance

Routine case-by-case notification to the federal level

3.0 Case Classification

3.1 Confirmed case

Clinical illness (see section 5.0) with laboratory confirmation of infection:

• Detection of IgM antibodies to hantavirus
  OR
• Detection of a significant (e.g. fourfold or greater) increase in hantavirus-specific IgG
  OR
• Detection of hantavirus RNA in an appropriate clinical specimen
  OR
• Detection of hantavirus antigen by immunohistochemistry

4.0 Laboratory Comments

5.0 Clinical Evidence

Clinical illness is characterized by:

• a febrile illness (temperature > 38.3°C (101°F) oral) requiring supplemental oxygen
  AND
• bilateral diffuse infiltrates (may resemble acute respiratory distress syndrome[ARDS])
  AND
• develops within 72 hours of hospitalization in a previously healthy person

OR

An unexplained illness resulting in death with an autopsy examination demonstrating noncardiogenic pulmonary edema without an identifiable specific cause of death

6.0 ICD Code(s)

6.1 ICD-10

B33.4

Hantavirus (cardio-) pulmonary syndrome

6.2 ICD-9CM

079.81

Hantavirus

7.0 Type of International Reporting

8.0 Comments

9.0 References

Date of Last Revision/Review:

May 2008