Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS)

Related Activities

The Antimicrobial Resistance Surveillance Unit has a developing risk assessment program that will evaluate surveillance data and other published literature with respect to antimicrobial use practices and assess potential antimicrobial resistance risk reduction measures. 

This program will support antimicrobial use policy development through the construction of a framework, sourcing of data, and identification of data gaps for undertaking quantitative and/or qualitative risk assessments on the human heath effects of antimicrobial use and resistance in Canadian food-animals.  Outputs from this project will provide assistance to PHAC, and to the Veterinary Drugs Directorate (Health Canada), and their Expert Advisory Committee on Antimicrobial Resistance Risk Assessments.  These outputs will facilitate policy development for approval of new antimicrobial products and re-evaluation of existing antimicrobial products, and will explore mathematical and statistical options for evaluating the human health impact of agri-food antimicrobial use primarily based on surveillance data generated by the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS).

Activities to date: 

1. Construction of a nonspecific qualitative template for antimicrobial resistance risk assessments (a flowchart of sources of risk, routes of exposure, types of outcomes)
2. Identification of data availability, data needs (and linkage to surveillance needs) for conducting such risk assessments (data sources for above template)

On-Going Activities

1. risk profile test case for the Veterinary Drugs Directorate , Health Canada
2. risk profile for ceftiofur (a third generation cephalosporin) use in Canadian food-animal production
3. in conjunction with the University of Guelph , evaluation of the use of tetracycline an antimicrobial growth promotant used in Ontario beef production
4. model development for estimating drug use in Canadian food-animals

New:
risk profile for cefquinome (a fourth generation cephalosporin) use in food-producing animals throughout the world

Papers Arising from Additional Analysis

• Salmonella Heidelberg – Ceftiofur-Related Resistance in Human and Retail Chicken Isolates
• Oral Macrolide Consumption in Canadian Provinces from 2000-2006