Public Health Agency of Canada
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Laboratory Biosafety Guidelines
3rd Edition 2004
PDF
Format (479 KB) 
Cat. No. H39-4/49-2004E-PDF
ISBN 0-662-37723-0
Table of Contents
Editorial Committee and Acknowledgements
2.1 Risk Groups
2.2 Containment Levels
2.3 Risk Assessment
2.4 Health and Medical
Surveillance
2.5 Management of Biological
Safety
2.6 Biosecurity
Chapter 3
Handling Infectious Substances
3.1 Operational Practices for
Laboratories
3.1.1 General Practices
3.1.2 Containment Level 2
3.1.3 Containment Level 3
3.1.4 Containment Level 4
Chapter 4
Laboratory Design and Physical Requirements
4.1 Matrix 1: Laboratory Location and
Access
4.2 Matrix 2: Surface Finishes and
Casework
4.3 Matrix 3: Heating, Ventilation and Air
Conditioning
4.4 Matrix 4: Containment
Perimeter
4.5 Matrix 5: Laboratory Services
Chapter 5
Commissioning, Certification and Recertification for CL3 and CL4
Laboratories
5.1 Introduction
5.1.1 Commissioning
5.1.2 Certification
5.1.3 Recertification
5.2 Room Integrity
5.2.1 Matrix 6: Room Integrity
5.2.2 Room Pressure Decay Testing
5.3 Air Handling Systems
5.3.1 Matrix 7: Air Handling
Systems
5.4 Matrix 8: Laboratory Equipment and
Services
Chapter 6
Large Scale Production of Microorganisms
6.1 Introduction
6.2 Scope
6.3 Operational Practices and Physical
Requirements
6.3.1 Containment Level 1 Large
Scale
6.3.2 Containment Level 2 Large
Scale
6.3.3 Containment Level 3 Large Scale
Chapter 7
Program Specific Guidelines
7.1 Laboratory animals
7.1.1 General Requirements
7.1.2 Non-human Primates
7.2 Recombinant DNA and Genetic
Manipulation
7.3 Cell Lines
7.3.1 Risk Assessment
7.3.2 Contamination with Infectious
Agents
7.3.3 Self-Self Experiments
8.1 Introduction
8.2 Autoclaves
8.3 Chemical Disinfection
8.4 Gaseous Decontamination of
Rooms
8.5 Liquid Effluent Treatment
Systems
8.6 Irradiation
8.7 Incineration
8.8 New Technologies
Chapter 9
Biological Safety Cabinets
9.1 Introduction
9.2 Classes and Characteristics of
Biological Safety Cabinets
9.3 Installation and
Certification
9.4 Use of the Cabinet
Chapter 10
Regulatory Aspects for Handling Infectious
Substances
10.1 Importation and Transfer of Human
Pathogens
10.2 Export of Pathogens
10.3 Transportation
10.4 Importation, Transfer, and
Containment of Animal Pathogens
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Please note that this document was published by Health Canada prior to the announcement of the establishment of the Public Health Agency of Canada on September 24, 2004. Any reference to Health Canada should be assumed to be to the Public Health Agency of Canada. |
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