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1900-1919
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| 1900 | Hamilton Steel and Iron Company is established |
| 1900 | Hamilton Incline Railway begins operation |
| 1900 | Hamilton Electric Light and Cataract Power Company Limited acquires Hamilton Street Railway and Hamilton Radial Electric Railway |
| 1902 | Canadian Otis Elevator Company is formed (August 22) |
| 1902 | Chipman-Holton Knitting Company Limited is established |
| 1902 | International Harvester Company sets up in Hamilton as International Harvester Company of Canada |
| 1902 | National Cycle and Automobile Company opens and closes in Hamilton |
| 1903 | E.D. Smith and Sons Limited produces first jam in Canada |
| 1903 | Hamilton Automobile Club is formed (April 29) |
| 1903 | Canadian Westinghouse Company Limited is incorporated (July 17) |
| 1903 | Canadian Canners Consolidated Companies Limited (later Canadian Canners Limited) formed |
| 1904 | Brantford and Hamilton Electric Railway is incorporated |
| 1905 | Hamilton, Grimsby, and Beamsville Electric Railway acquired by Hamilton Electric Light and Cataract Power Company Limited |
| 1905 | Canadian Otis Elevator Company merges with Fensom Company to become Otis-Fensom Elevator Company |
| 1906 | A violent strike occurs at Hamilton Street Railway (November) |
| 1906 | Brantford and Hamilton Electric Railway is acquired by Hamilton Electric Light and Cataract Power Company Limited |
| 1906 | Hydro-Electric Power Commission of Ontario (later Ontario Hydro) is formed |
| 1907 | The Independent Labour Party is founded |
| 1907 | Hamilton Electric Light and Cataract Power Company Limited is reorganized as Dominion Power and Transmission Company |
| 1910 | Gurney, Tilden Company is acquired by Hamilton Stove and Heater Company |
| 1910 | Canada Bolt and Nut Company is established |
| 1910 | Steel Company of Canada Limited (Stelco) is formed (June 8) |
| 1910 | Canada Steel Company (later Burlington Steel Limited) founded |
| 1910 | Canadian Canners Limited expanded and renamed Dominion Canners Limited |
| 1910 | Acme Motor Carriage and Machinery Company Limited comes to Hamilton |
| 1911 | Schacht Motor Car Company of Canada Limited sets up in Hamilton |
| 1912 | Dominion Steel Casting Company (Dofasco) founded |
| 1912 | Acme Motor Carriage and Machinery Company closes in Hamilton |
| 1912 | Imperial Car Company (later National Steel Car Company) is founded (June 12) |
| 1912 | Mercury Mills Company Limited is founded (December 20) |
| 1913 | Schacht Motor Car Company closes |
| 1913 | Procter and Gamble Manufacturing Company sets up Canadian operations in Hamilton |
| 1914 | World War I (August 4: Great Britain declares war on Germany) |
| 1917 | Stater and Barnard Company founded |
| 1918 | World War I ends (November 11) |
| 1919 | Hoover Suction Sweeper Company builds a plant in Hamilton |
| 1919 | Firestone Tire and Rubber Company of Canada is established |
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