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1880-1899
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| 1880 | Tucket and Billings firm is renamed George E. Tuckett and Son, and later Tuckett Tobacco Company Limited |
| 1880 | Hamilton Cotton Company founded |
| 1881 | Canada's first active assembly of the Knights of Labour is formed in Hamilton |
| 1881 | Ontario Cotton Mills (later Canadian Cottons Limited) is established |
| 1882 | E.D. Smith and Sons Limited is established |
| 1882 | Grand Trunk Railway acquires Great Western Railway (August 12) |
| 1883 | Dominion Wire Manufacturing Company is established in Lachine, Quebec |
| 1884 | Toronto, Hamilton, and Buffalo Railway is incorporated |
| 1885 | Gurney and Ware Scale Company is renamed Gurney Scale Company |
| 1888 | North and Northwestern Railway is acquired by the Grand Trunk Railway |
| 1889 | Train derails on Grand Trunk Railway track (April 28) |
| 1889 | L.D. Sawyer and Company is renamed Sawyer and Massey Company Limited |
| 1891 | Hamilton, Grimsby, and Beamsville Electric Railway project begun |
| 1891 | Dundas Cotton Manufacturing Company closes |
| 1892 | Toronto, Hamilton, and Buffalo Railway amalgamates with Brantford, Waterloo, and Lake Erie Railway |
| 1892 | Hamilton and Barton Incline Railway is constructed |
| 1892 | R.M. Wanzer goes bankrupt; stops manufacturing sewing machines |
| 1892 | Hamilton Street Railway replaces horse-drawn cars with electrically-driven trolley cars (July) |
| 1893 | E. and C. Gurney Company is split into Gurney Foundry Company and Gurney, Tilden Company |
| 1893 | Hamilton Radial Electric Railway project is begun |
| 1894 | Hamilton Tool Works renamed Hamilton Bridge Works Company Limited |
| 1896 | Gartshore-Thomson Pipe and Foundry Company Limited is incorporated |
| 1896 | Westinghouse Air Brake Manufacturing Company comes to Hamilton |
| 1896 | Cataract Power Company of Hamilton Limited is organized |
| 1898 | First automobile is driven in Hamilton (April 12) |
| 1899 | Hamilton and Dundas Street Railway is acquired by Cataract Power Company |
| 1899 | Cataract Power Company Limited acquires Hamilton Electric Light and Power Company; renamed Hamilton Electric Light and Cataract Power Company Limited |
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